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SARS-CoV-2, COVID-19 and the aging immune system

Updated: Sep 12, 2023

Recent advances in the science of aging have highlighted how aging pathways control not only lifespan but also healthspan - the healthy years of life. Here, we discuss the aging immune system and its ability to respond to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

We specifically focus on the intersection of severe COVID-19 and immunosenescence to highlight pathways that may be determinant of the risk of complications and death following infection with SARS-CoV-2.

New or adapted therapeutics that target aging-associated pathways may be important tools to reduce the burden of death and long-term disability caused by this pandemic.

Proposed interventions aimed at immunosenescence could enhance immune function not only in older adults but in susceptible younger individuals as well, ultimately improving complications of severe COVID-19 for all ages. Read more on

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